A direct route to triazole boronic esters and their application in the synthesis of small molecule arrays

被引:22
作者
Huang, Jianhui [1 ]
Macdonald, Simon J. F. [2 ]
Cooper, Anthony W. J. [2 ]
Fisher, Gail [2 ]
Harrity, Joseph P. A. [1 ]
机构
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] GlaxoSmithKline Res & Dev Ltd, Stevenage SG1 2NY, Herts, England
基金
英国工程与自然科学研究理事会;
关键词
MEDIATED 2+2+2 CYCLOADDITION; DIELS-ALDER; DERIVATIVES; ALKYNES; SCOPE;
D O I
10.1016/j.tetlet.2009.07.085
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Alkynylboronates represent useful substrates for the direct synthesis of triazole boronic esters by their thermal cycloaddition with azides. A telescoped cycloaddition-cross-coupling protocol is reported and its employment in the synthesis of a small triazole array is disclosed. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5539 / 5541
页数:3
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