Total Synthesis of (-)- and (+)-Tedanalactam

被引：24

作者：

Majik, Mahesh S. ^{[1
]}

Parameswaran, Perunninakulath S. ^{[2
]}

Tilve, Santosh G. ^{[1
]}

机构：

[1] Goa Univ, Dept Chem, Taleigao Plateau 403206, Goa, India

[2] Natl Inst Oceanog, Panaji 403004, Goa, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 16期

关键词：

OXIDATION-WITTIG REACTION; ASYMMETRIC DIHYDROXYLATION; PIPERIDINES; DISCOVERY; ACID;

D O I：

10.1021/jo901143b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first stereoselective route providing access to both enantiomers of tedanalactam. a naturally occurring piperidone, has been developed. The stereogenic centers were generated by the use of Sharpless asymmetric dihydroxylation. Tandem oxidation-Wittig reaction and one-pot deprotection, lactamization, and oxirane ring formation are the other key elements.

引用

页码：6378 / 6381

页数：4

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