Insulin Resistance Is Associated With Decreased Quadriceps Muscle Strength in Nondiabetic Adults Aged ≥70 Years

被引:108
作者
Barzilay, Joshua I. [1 ,2 ]
Cotsonis, George A. [3 ]
Walston, Jeremy [4 ]
Schwartz, Ann V. [5 ]
Satterfield, Suzanne [6 ]
Miljkovic, Iva [7 ]
Harris, Tamara B. [8 ]
机构
[1] Kaiser Permanente Georgia, Atlanta, GA USA
[2] Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA
[3] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA USA
[4] Johns Hopkins Med Inst, Dept Geriatr, Baltimore, MD 21205 USA
[5] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[6] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA
[7] Univ Pittsburgh, Ctr Aging & Populat Hlth, Pittsburgh, PA USA
[8] NIA, Geriatr Epidemiol Sect, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
BODY-COMPOSITION; SKELETAL-MUSCLE; HEALTH; SENSITIVITY; GLUCOSE;
D O I
10.2337/dc08-1781
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - Lower-limb muscle strength is reduced in many people with diabetes. In this Study, we examined whether quadriceps muscle strength is reduced in relation to insulin resistance in well-functioning ambulatory nondiabetic individuals. RESEARCH DESIGN AND METHODS - Participants (age >= 70 years) underwent dual-energy X-ray absorptiometry (DEXA) scanning to ascertain muscle and fat mass, tests of quadriceps strength, computed tomography scanning Of the quadriceps to gauge muscle lipid content, and fasting insulin and glucose level measurements from which homeostasis model assessment of insulin resistance (HOMA-IR) was derived. RESULTS - In regression analysis, quadriceps strength per kilogram of muscle mass was negatively associated (P < 0.0001) with HOMA-IR independent of other factors negatively associated with strength such as increased age, female sex, low-physical activity, impaired fasting glucose, and increased total body fat. Muscle lipid content was not associated with strength. CONCLUSIONS - A shall decrease in quadriceps muscle force is associated with increased HOMA-IR in well-functioning nondiabetic adults, suggesting that diminished quadriceps muscle strength begins before diabetes.
引用
收藏
页码:736 / 738
页数:3
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