Vascular Endothelial Growth Factor in Acute Lung Injury and Acute Respiratory Distress Syndrome

被引：84

作者：

Barratt, S. ^{[1
,3
]}

Medford, A. R. ^{[2
,3
]}

Millar, A. B. ^{[1
,3
]}

机构：

[1] Univ Bristol, Acad Resp Unit, Bristol, Avon, England

[2] Univ Bristol, North Bristol Lung Ctr, Bristol, Avon, England

[3] Univ Bristol, Southmead Hosp, Bristol, Avon, England

来源：

RESPIRATION | 2014年 / 87卷 / 04期

关键词：

Acute lung injury; Acute respiratory distress syndrome; Vascular endothelial growth factor; FACTOR VEGF; FACTOR-B; TUMOR-CELLS; FACTOR GENE; SIGNAL-TRANSDUCTION; FACTOR RECEPTOR; PERMEABILITY FACTOR; VESSEL ENLARGEMENT; FACTOR BIOACTIVITY; FACTOR CONTRIBUTES;

D O I：

10.1159/000356034

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Acute respiratory distress syndrome (ARDS) is the most severe form of lung injury, characterised by alveolar oedema and vascular permeability, in part due to disruption of the alveolar capillary membrane integrity. Vascular endothelial growth factor (VEGF) was originally identified as a vascular permeability factor and has been implicated in the pathogenesis of acute lung injury/ARDS. This review describes our current knowledge of VEGF biology and summarises the literature investigating the potential role VEGF may play in normal lung maintenance and in the development of lung injury.

引用

页码：329 / 342

页数：14

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