Structure and mechanism of proton-translocating transhydrogenase

被引：47

作者：

Jackson, JB ^{[1
]}

Peake, SJ ^{[1
]}

White, SA ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

FEBS LETTERS | 1999年 / 464卷 / 1-2期

基金：

英国惠康基金;

关键词：

transhydrogenase; membrane protein; proton translocation; x-ray structure; nucleotide binding;

D O I：

10.1016/S0014-5793(99)01644-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments have led to advances in our understanding of the structure and mechanism of action of proton-translocating (or AB) transhydrogenase. There is (a) a high-resolution crystal structure, and an NMR structure, of the NADP(H)-binding component (dIII), (b) a homology-based model of the NAD(H)-binding component (dI) and (c) an emerging consensus on the position of the transmembrane heliccs (in dII), The crystal structure of dIII, in particular, provides new insights into the mechanism by which the energy released in proton translocation across the membrane is coupled to changes in the binding affinities of NADP(+) and NADPH that drive the chemical reaction. (C) 1999 Federation of European Biochemical Societies.

引用

页码：1 / 8

页数：8

共 73 条

[1] Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase [J].

Baker, PJ ;

Sawa, Y ;

Shibata, H ;

Sedelnikova, SE ;

Rice, DW .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (07) :561-567

[2] Protein motifs .9. The nicotinamide dinucleotide binding motif: A comparison of nucleotide binding proteins [J].

Bellamacina, CR .

FASEB JOURNAL, 1996, 10 (11) :1257-1269

[3] The pH dependences of reactions catalyzed by the complete proton-translocating transhydrogenase from Rhodospirillum rubrum, and by the complex formed from its recombinant nucleotide-binding domains [J].

Bizouam, T ;

Stilwell, S ;

Venning, J ;

Cotton, NPJ ;

Jackson, JB .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1997, 1322 (01) :19-32

[4] The binding of nucleotides to domain I proteins of the proton-translocating transhydrogenases from Rhodospirillum rubrum and Escherichia coli as measured by equilibrium dialysis [J].

Bizouarn, T ;

Diggle, C ;

Jackson, JB .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 239 (03) :737-741

[5] THE INVOLVEMENT OF NADP(H) BINDING AND RELEASE IN ENERGY TRANSDUCTION BY PROTON-TRANSLOCATING NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE FROM ESCHERICHIA-COLI [J].

BIZOUARN, T ;

GRIMLEY, RL ;

COTTON, NPJ ;

STILWELL, SN ;

HUTTON, M ;

JACKSON, JB .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1995, 1229 (01) :49-58

[6] Mutations at tyrosine-235 in the mobile loop region of domain I protein of transhydrogenase from Rhodospirillum rubrum strongly inhibit hydride transfer [J].

Bizouarn, T ;

Grimley, R ;

Diggle, C ;

Thomas, CM ;

Jackson, JB .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1997, 1320 (03) :265-274

[7] Interaction of nucleotides with the NAD(H)-binding domain of the proton-translocating transhydrogenase of Rhodospirillum rubrum [J].

Bizouarn, T ;

Diggle, C ;

Quirk, PG ;

Grimley, RL ;

Cotton, NPJ ;

Thomas, CM ;

Jackson, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (17) :10103-10108

[8] Estimation of the H+/H- ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase in chromatophores from over-expressing strains of Rhodospirillum rubrum and in liposomes inlaid with the purified bovine enzyme [J].

Bizouarn, T ;

Sazanov, LA ;

Aubourg, S ;

Jackson, JB .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1996, 1273 (01) :4-12

[9] THE RATIO OF PROTONS TRANSLOCATED HYDRIDE ION EQUIVALENT TRANSFERRED BY NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE IN CHROMATOPHORES FROM RHODOSPIRILLUM-RUBRUM [J].

BIZOUARN, T ;

JACKSON, JB .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 217 (02) :763-770

[10] The udhA gene of Escherichia coli encodes a soluble pyridine nucleotide transhydrogenase [J].

Boonstra, B ;

French, CE ;

Wainwright, I ;

Bruce, NC .

JOURNAL OF BACTERIOLOGY, 1999, 181 (03) :1030-1034

← 1 2 3 4 5 6 7 8 →