A1/A2 polymorphism of GpIIIa gene and a risk of aneurysmal subarachnoid haemorrhage

被引：9

作者：

Adamski, Mateusz G. ^{[1
]}

Borratynska, Anna ^{[1
]}

Krupa, Mariusz ^{[2
]}

Wloch-Kopec, Dorota ^{[1
]}

Turaj, Wojciech ^{[1
]}

Wolkow, Pawel ^{[3
]}

Wnuk, Marcin ^{[1
]}

Urbanik, Andrzej ^{[4
]}

Moskala, Marek ^{[2
]}

Szczudlik, Andrzej ^{[1
]}

Slowik, Agnieszka ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Neurol, PL-310503 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Neurosurg & Neurotraumatol, PL-310503 Krakow, Poland

[3] Jagiellonian Univ, Coll Med, Dept Pharmacol, PL-310503 Krakow, Poland

[4] Jagiellonian Univ, Coll Med, Dept Radiol, PL-310503 Krakow, Poland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 383卷 / 02期

关键词：

GpIIIa; GpIIIa A1/A2 polymorphism; Aneurysmal SAH; CIGARETTE-SMOKING; DISEASE; INTEGRIN; COMPLEX;

D O I：

10.1016/j.bbrc.2009.03.156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet glycoproteins are involved in pathophysiology of cerebrovascular diseases. The aim of this study was to investigate the association between the GpIIIa gene A1/A2 polymorphism and a risk of aneurysmal subarachnoid haemorrhage (SAH) in a Polish population. In a case-control study we genotyped 288 Caucasian patients with aneurysmal SAH and 457 age- ,gender- and race-matched controls. The GpIIIa A1/A2 polymorphism was genotyped with RFLP technique. No difference was found in the distribution of the polymorphism between the cases and controls (cases: A1A1-201 (69.8%). A1A2-83 (28.8%) and A2A2-4(1.4%)vs. controls: A1A1-323 (70.7%); A1A2-128 (28.0%); A2A2-6(1.3%), P > 0.05. In a multivariate analysis female gender (OR=1.950: 95%CI: 1.308-2.907), hypertension (OR=4.774; 95%CI: 3.048-7.478) and smoking (OR = 2.034: 95%CI: 1.366-3.030), but not GpIIIa A1/A2 polymorphism, were independent risk factors for aneurysmal SAH. The GpIIIa A1/A2 polymorphism is not a risk factor of aneurysmal SAH in a Polish population. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：228 / 230

页数：3

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