JC virus induces a vigorous CD8+ cytotoxic T cell response in multiple sclerosis patients

被引：23

作者：

Du Pasquier, Renaud A.

Stein, Marion C.

Lima, Marco A.

Dang, Xin

Jean-Jacques, Jims

Zheng, Yue

Letvin, Norman L.

Koralnik, Igor J.

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02115 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 176卷 / 1-2期

关键词：

multiple sclerosis; myelin; progressive multifocal leukoencephalopathy; JC virus; natalizumab; CD8(+)T cells;

D O I：

10.1016/j.jneuroim.2006.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We sought to compare the ongoing CD8(+) cytotoxic T lymphocytes (CTL) immune response of MS patients to self and viral antigens. Using Cr-51 release and tetramer staining assays, we found that the CTL response against VP1, the major capsid protein of the polyomavirus JC (JCV), was significantly higher than the one against epitopes of MBP and PLP. The JCV-specific CTL response was also significantly stronger in MS patients than healthy control subjects. These findings may shed a new light on the recent events related to the development of progressive multifocal leukoencephalopathy in three natalizumab-treated patients. (c) 2006 Elsevier B.V. All rights reserved.

引用

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页码：181 / 186

页数：6

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