Cyclophilins: unexpected messengers in intercellular communications

被引：83

作者：

Bukrinsky, MI ^{[1
]}

机构：

[1] George Washington Univ, Dept Microbiol & Trop Med, Washington, DC 20037 USA

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 07期

关键词：

D O I：

10.1016/S1471-4906(02)02237-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cyclophilins are abundant cellular proteins best known for their affinity for the immunosuppressive drug cyclosporin A. Until now, the physiological roles of cyclophilins were limited to intracellular functions. A recent paper by Allain and colleagues demonstrates that extracellular cyclophilin B specifically enhances chemotaxis and adhesion of the memory CD4(+) T cells. This effect also requires glycosaminoglycans, thus adding cyclophilin B to other glycosaminoglycan-dependent factors that regulate leukocyte trafficking.

引用

页码：323 / 325

页数：3

共 24 条

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