Thalidomide as an emerging immunotherapeutic agent

被引：113

作者：

Marriott, JB

Muller, G

Dalgleish, AG

机构：

[1] Univ London St Georges Hosp, Sch Med, Dept Cellular & Mol Sci, Div Oncol, London SW17 0RE, England

[2] Celgene Corp, Warren, NJ 07059 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(99)01531-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thalidomide first hit the headlines with alarming reports of birth defects after pregnant women took the drug to combat morning sickness. Now, the drug has been shown to have important immunomodulatory and anti-inflammatory effects that may be useful in the treatment of AIDS and cancer.

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收藏

页码：538 / 540

页数：3

相关论文

共 52 条

[1] A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers [J].

Alexander, LN ;

Wilcox, CM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (04) :301-304

[2]

ANDERSON JM, 1997, NEW ENGL J MED, V336, P1487

[3]

Azuma A, 1996, BIOL PHARM BULL, V19, P1001

[4]

CHEN TL, 1989, DRUG METAB DISPOS, V17, P402

[5] Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity [J].

Corral, LG ;

Muller, GW ;

Moreira, AL ;

Chen, YX ;

Wu, MD ;

Stirling, D ;

Kaplan, G .

MOLECULAR MEDICINE, 1996, 2 (04) :506-515

[6] THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS [J].

DAMATO, RJ ;

LOUGHNAN, MS ;

FLYNN, E ;

FOLKMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4082-4085

[7]

EHNINGER G, 1993, BONE MARROW TRANSPL, V12, pS26

[8] Taming TNF: strategies to restrain this proinflammatory cytokine [J].

Eigler, A ;

Sinha, B ;

Hartmann, G ;

Endres, S .

IMMUNOLOGY TODAY, 1997, 18 (10) :487-492

[9] STEREOSPECIFIC DETERMINATION, CHIRAL INVERSION IN-VITRO AND PHARMACOKINETICS IN HUMANS OF THE ENANTIOMERS OF THALIDOMIDE [J].

ERIKSSON, T ;

BJORKMAN, S ;

ROTH, B ;

FYGE, A ;

HOGLUND, P .

CHIRALITY, 1995, 7 (01) :44-52

[10] Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre [J].

Fife, K ;

Howard, MR ;

Gracie, F ;

Phillips, RH ;

Bower, M .

INTERNATIONAL JOURNAL OF STD & AIDS, 1998, 9 (12) :751-755

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