Endogenous Regulation of Inflammatory Pain by T-cell-derived Opioids: When Friend Turns to Foe

被引：14

作者：

Basso, Lilian ^{[1
,2
,3
]}

Boue, Jerome ^{[1
,2
,3
]}

Bourreille, Arnaud ^{[4
,5
]}

Dietrich, Gilles ^{[1
,2
,3
]}

机构：

[1] INSERM, U1043, F-31024 Toulouse 03, France

[2] CNRS, Unit 5282, Toulouse, France

[3] Univ Toulouse, UPS, Ctr Physiopathol Toulouse Purpan, Toulouse, France

[4] INSERM, U913, Nantes, France

[5] Univ Nantes, Inst Malad Appareil Digestif, Nantes, France

来源：

INFLAMMATORY BOWEL DISEASES | 2014年 / 20卷 / 10期

关键词：

inflammatory pain; opioids; T lymphocyte; analgesia; colitis; Crohn's disease; DORSAL-ROOT GANGLIA; RECEPTOR MESSENGER-RNA; CROHNS-DISEASE; VISCERAL PAIN; UP-REGULATION; TH17; CELLS; TRANSCRIPTIONAL REGULATION; INTESTINAL INFLAMMATION; FUNCTIONAL COMPETENCE; BETA-ENDORPHIN;

D O I：

10.1097/MIB.0000000000000073

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Painful sensation is a hallmark of microbe-induced inflammation. This inflammatory pain is downregulated a few days after infection by opioids locally released by effector T lymphocytes generated in response to microbe-derived antigens. This review focuses on the endogenous regulation of inflammatory pain associated with adaptive T-cell response and puts in perspective the clinical consequences of the opioid-mediated analgesic activity of colitogenic T lymphocytes in inflammatory bowel disease.

引用

页码：1870 / 1877

页数：8

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