Proteomic phenotyping: metastatic and invasive breast cancer

被引：22

作者：

Hathout, Y ^{[1
]}

Gehrmann, ML ^{[1
]}

Chertov, A ^{[1
]}

Fenselau, C ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

CANCER LETTERS | 2004年 / 210卷 / 02期

关键词：

MCF-7/ADR; adriamycin; breast cancer cell lines; proteome phenotyping; metastasis;

D O I：

10.1016/j.canlet.2004.01.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The adriamycin resistant breast cancer cell line (MCF-7/ADR) is a subject of ongoing debate concerning its origin and or source. Previous studies in our laboratory showed that MCF-7/ADR has a unique cytosolic protein expression pattern when compared to that of the parental MCF-7 cell line and other drug resistant MCF-7 cell lines. Protein expression patterns obtained using two-dimensional gel electrophoresis and mass spectrometry indicated that this MCF-7/ADR cell line shares some similarities with the metastatic breast cancer cell lines MDA-MB. Further comparisons with available two-dimensional gel electrophoresis maps in the literature indicate that MCF-7/ADR has a protein expression signature even closer to of the ductal infiltrating breast carcinoma cell line 8701. These observations suggest that MCF-7/ADR cells might have originated in a selection of ductal infiltrating carcinoma cells, which were present among the original MCF-7 cell population. These ductal infiltrating carcinoma cells may possess an intrinsic adriamycin resistance phenotype. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 253

页数：9

共 34 条

[1]

BATIST G, 1986, J BIOL CHEM, V261, P5544

[2]

Brichory F, 2001, CANCER RES, V61, P7908

[3]

BROOKS SC, 1973, J BIOL CHEM, V248, P6251

[4]

CAILLEAU R, 1978, IN VITRO CELL DEV B, V14, P911

[5] PROGESTERONE-RECEPTOR HETEROGENEITY IN MCF-7 CELL SUBCLONES IS RELATED TO CLONAL ORIGIN AND KINETICS DATA [J].

CASSANELLI, S ;

LOUIS, J ;

SEIGNEURIN, D .

TUMOR BIOLOGY, 1995, 16 (04) :222-229

[6]

CHEN YN, 1990, J BIOL CHEM, V265, P10073

[7]

Dawling S, 2001, CANCER RES, V61, P6716

[8]

De Larco JE, 2001, CANCER RES, V61, P2857

[9]

Devarajan E, 2002, INT J ONCOL, V20, P913

[10] A multidrug resistance transporter from human MCF-7 breast cancer cells [J].

Doyle, LA ;

Yang, WD ;

Abruzzo, LV ;

Krogmann, T ;

Gao, YM ;

Rishi, AK ;

Ross, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15665-15670

← 1 2 3 4 →