Transcriptional control of adipocyte formation

被引：1526

作者：

Farmer, Stephen R. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

来源：

CELL METABOLISM | 2006年 / 4卷 / 04期

关键词：

D O I：

10.1016/j.cmet.2006.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A detailed understanding of the processes governing adipose tissue formation will be instrumental in combating the obesity epidemic. Much progress has been made in the last two decades in defining transcriptional events controlling the differentiation of mesenchymal stem cells into adipocytes. A complex network of transcription factors and cell-cycle regulators, in concert with specific transcriptional coactivators and corepressors, respond to extracellular stimuli to activate or repress adipocyte differentiation. This review summarizes advances in this field, which constitute a framework for potential antiobesity strategies.

引用

页码：263 / 273

页数：11

共 102 条

[1] Conditional deletion of β-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium
Arango, NA
Szotek, PP
Manganaro, TF
Oliva, E
Donahoe, PK
Teixeira, J
[J]. DEVELOPMENTAL BIOLOGY, 2005, 288 (01) : 276 - 283
[2] The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-γ expression and adipogenesis
Banerjee, SS
Feinberg, MW
Watanabe, M
Gray, S
Haspel, RL
Denkinger, DJ
Kawahara, R
Hauner, H
Jain, MK
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (04) : 2581 - 2584
[3] PPARγ is required for placental, cardiac, and adipose tissue development
Barak, Y
Nelson, MC
Ong, ES
Jones, YZ
Ruiz-Lozano, P
Chien, KR
Koder, A
Evans, RM
[J]. MOLECULAR CELL, 1999, 4 (04) : 585 - 595
[4] INHIBITION OF ADIPOGENESIS BY THE STRESS-INDUCED PROTEIN CHOP (GADD153)
BATCHVAROVA, N
WANG, XZ
RON, D
[J]. EMBO JOURNAL, 1995, 14 (19) : 4654 - 4661
[5] Regulation of osteoblastogenesis and bone mass by Wnt10b
Bennett, CN
Longo, KA
Wright, WS
Suva, LJ
Lane, TF
Hankenson, KD
MacDougald, OA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (09) : 3324 - 3329
[6] Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein β, implicated in adipocyte differentiation
Bezy, O
Elabd, C
Cochet, O
Petersen, RK
Kristiansen, K
Dani, C
Ailhaud, R
Amri, EZ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (12) : 11432 - 11438
[7] Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells
Blumberg, JM
Tzameli, I
Astapova, I
Lam, FS
Flier, JS
Hollenberg, AN
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (16) : 11205 - 11213
[8] Overexpression of Stra13 a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells
Boudjelal, M
Taneja, R
Matsubara, S
Bouillet, P
Dolle, P
Chambon, P
[J]. GENES & DEVELOPMENT, 1997, 11 (16) : 2052 - 2065
[9] REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS
CAO, ZD
UMEK, RM
MCKNIGHT, SL
[J]. GENES & DEVELOPMENT, 1991, 5 (09) : 1538 - 1552
[10] Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
Chen, PL
Riley, DJ
Chen, YM
Lee, WH
[J]. GENES & DEVELOPMENT, 1996, 10 (21) : 2794 - 2804

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