The NPAS3 gene -: emerging evidence for a role in psychiatric illness

被引：40

作者：

Pickard, Benjamin S. ^{[1
]}

Pieper, Andrew A.

Porteous, David J.

Blackwood, Douglas H.

Muir, Walter J.

机构：

[1] Univ Edinburgh, Med Genet Sect, Sch Clin & Mol Med, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75230 USA

[3] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75230 USA

[4] Univ Edinburgh, Royal Edinburgh Hosp, Edinburgh, Midlothian, Scotland

来源：

ANNALS OF MEDICINE | 2006年 / 38卷 / 06期

基金：

英国医学研究理事会;

关键词：

behaviour; bipolar disorder; hippocampus; knock-out; neurogenesis; schizophrenia; transcription factor; translocation;

D O I：

10.1080/07853890600946500

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

引用

页码：439 / 448

页数：10

共 100 条

[1] Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise [J].

Alonso, CR .

BIOESSAYS, 2005, 27 (05) :463-466

[2] Ultraconserved elements in the human genome [J].

Bejerano, G ;

Pheasant, M ;

Makunin, I ;

Stephen, S ;

Kent, WJ ;

Mattick, JS ;

Haussler, D .

SCIENCE, 2004, 304 (5675) :1321-1325

[3] Genetics of psychiatric disease [J].

Berrettini, WH .

ANNUAL REVIEW OF MEDICINE, 2000, 51 :465-479

[4] Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia [J].

Blackwood, DHR ;

Muir, WJ .

NEUROTOXICITY RESEARCH, 2004, 6 (01) :35-41

[5] Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 [J].

Blouin, JL ;

Dombroski, BA ;

Nath, SK ;

Lasseter, VK ;

Wolyniec, PS ;

Nestadt, G ;

Thornquist, M ;

Ullrich, G ;

McGrath, J ;

Kasch, L ;

Lamacz, M ;

Thomas, MG ;

Gehrig, C ;

Radhakrishna, U ;

Snyder, SE ;

Balk, KG ;

Neufeld, K ;

Swartz, KL ;

DeMarchi, N ;

Papadimitriou, GN ;

Dikeos, DG ;

Stefanis, CN ;

Chakravarti, A ;

Childs, B ;

Housman, DE ;

Kazazian, HH ;

Antonarakis, SE ;

Pulver, AE .

NATURE GENETICS, 1998, 20 (01) :70-73

[6] Carbon monoxide and clocks [J].

Boehning, D ;

Snyder, SH .

SCIENCE, 2002, 298 (5602) :2339-2340

[7] Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders [J].

Brown, ES ;

Rush, AJ ;

McEwen, BS .

NEUROPSYCHOPHARMACOLOGY, 1999, 21 (04) :474-484

[8] Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis [J].

Brown, J ;

Cooper-Kuhn, CM ;

Kempermann, G ;

Van Praag, H ;

Winkler, J ;

Gage, FH ;

Kuhn, HG .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (10) :2042-2046

[9] Characterization of Npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system [J].

Brunskill, EW ;

Witte, DP ;

Shreiner, AB ;

Potter, SS .

MECHANISMS OF DEVELOPMENT, 1999, 88 (02) :237-241

[10] Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice [J].

Brunskill, EW ;

Ehrman, LA ;

Williams, MT ;

Klanke, J ;

Hammer, D ;

Schaefer, TL ;

Sah, R ;

Dorn, GW ;

Potter, SS ;

Vorhees, CV .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (06) :1265-1276

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