Isolation and stereochemistry of two new alkaloids from Stemona tuberosa

被引：55

作者：

Jiang, RW

Hon, PM

But, PPH

Chung, HS

Lin, G

Ye, WC

Mak, TCW ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China

[5] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

来源：

TETRAHEDRON | 2002年 / 58卷 / 33期

关键词：

Stemona tuberosa; neotuberostemonol; neotuberostemoninol; neomberostemonine; hydrogen bonds;

D O I：

10.1016/S0040-4020(02)00678-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new stenine-type alkaloids, neotuberostemonol (3) and neotuberostemoninol (4), along with the known compound neotuberostemonine (2), were isolated from Stemona tuberosa Lour. Their structures were characterized by X-ray crystallography in combination with spectroscopic methods, and their absolute configurations were inferred from the known configuration of tuberostemonine (1). In the crystalline state, weak C-H...O hydrogen bonds play an important role in the molecular packing of 3 and 4. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6705 / 6712

页数：8

共 50 条

[1]

BRUKER, 1998, SMART 5 0 SAINT 5 0

[2] A DIELS-ALDER APPROACH TO STEMONA ALKALOIDS - TOTAL SYNTHESIS OF STENINE [J].