'Cap-tabolism'

被引：88

作者：

Cougot, N ^{[1
]}

van Dijk, E ^{[1
]}

Babajko, S ^{[1
]}

Séraphin, B ^{[1
]}

机构：

[1] Univ Paris 06, CNRS UPR2167, Equpe Labellisee La Ligue, Ctr Mol Genet, F-91198 Gif Sur Yvette, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2004.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A distinctive feature of eukaryotic mRNA and small nuclear RNA (snRNA) that are transcribed by RNA polymerase II (Pol II) is the presence of a cap structure at their 5' end. This essential modification serves as an inviting 'landing pad' for factors that are involved in various cellular processes such as pre-mRNA splicing, nucleocytoplasmic RNA export and localization, and translation initiation. Because of the important functions mediated by the mRNA cap, this structure needs to be modified and/or degraded in a tightly controlled manner. Several cellular and viral systems implicated in cap metabolism have been uncovered recently; their analyses provide interesting new information on cell structure and function.

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页码：436 / 444

页数：9

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