The chemoenzymatic synthesis of usnic acid

被引：22

作者：

Hawranik, Drew J. ^{[1
]}

Anderson, Kurtis S. ^{[1
]}

Simmonds, Reesa ^{[1
]}

Sorensen, John. L. ^{[1
]}

机构：

[1] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Natural products; Usnic acid; Polyketide; Lichens; Organic synthesis; Enzyme oxidation; Horseradish peroxidase;

D O I：

10.1016/j.bmcl.2009.03.087

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Usnic acid, a highly functionalized dibenzofuran, is a polyketide secondary metabolite produced by several species of lichens. Synthesis of usnic acid from commercially available starting material was accomplished in two steps. The synthesis involves the methylation of phloracetophenone followed by oxidation with horseradish peroxidase. This work will lay the foundation for further biosynthetic studies on usnic acid. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2383 / 2385

页数：3

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