Catalytic asymmetric synthesis of α-amino phosphonates using enantioselective carbon-carbon bond-forming reactions

被引：95

作者：

Kobayashi, S ^{[1
]}

Kiyohara, H ^{[1
]}

Nakamura, Y ^{[1
]}

Matsubara, R ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 21期

关键词：

D O I：

10.1021/ja048791i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed highly enantioselelctive reactions of silicon enolates with N-acyl-α-iminophosphonates leading to optically active α-amino phophonates. A copper (II)-diamine complex was shown to be effective in this reaction, and high levels of yield and selectivity were achieved. It is noteworthy that this reaction opens a way to various biologically important, optically active α-amino phosphonate derivatives. Copyright © 2004 American Chemical Society.

引用

页码：6558 / 6559

页数：2

共 25 条

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