Nef enhances human immunodeficiency virus type 1 infectivity in the absence of matrix

被引：20

作者：

Dorfman, T

Popova, E

Pizzato, M

Göttlinger, HG

机构：

[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 13期

关键词：

D O I：

10.1128/JVI.76.13.6857-6862.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nef enhances the serine phosphorylation of the human immunodeficiency virus type 1 matrix (MA) protein, which suggests that MA may be a functional target of Nef. Using mutants that remain infectious despite the absence of most or all of MA, we show in the present study that the ability of Nef to enhance virus infectivity is not compromised even if MA is entirely replaced by a heterologous lipid anchor.

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收藏

页码：6857 / 6862

页数：6

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