C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

被引：70

作者：

Brandsen, J

Werten, S

vanderVliet, PC

Meisterernst, M

Kroon, J

Gros, P

机构：

[1] UNIV UTRECHT,BIJVOET CTR BIOMOL RES,DEPT CRYSTAL & STRUCT CHEM,UTRECHT,NETHERLANDS

[2] UNIV UTRECHT,PHYSIOL CHEM LAB,NL-3521 GG UTRECHT,NETHERLANDS

[3] UNIV UTRECHT,BIJVOET CTR BIOMOL RES,DEPT NMR SPECT,UTRECHT,NETHERLANDS

[4] UNIV MUNICH,GENZENTRUM,MOL BIOL LAB,MUNICH,GERMANY

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 11期

关键词：

D O I：

10.1038/nsb1197-900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of human replication and transcription cofactor PC4(CTD) reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

引用

页码：900 / 903

页数：4

共 29 条

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