CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization
被引:97
作者:
Jenkins, Noah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USAUniv Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA
Jenkins, Noah
[1
]
Saam, Jennifer R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USAUniv Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA
Saam, Jennifer R.
[1
]
Mango, Susan E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USAUniv Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA
Mango, Susan E.
[1
]
机构:
[1] Univ Utah, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA
The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity. These data suggest that CYK-4 provides a molecular link between fertilization and polarity establishment in the one-cell embryo. Orthologs of CYK-4 are expressed in sperm of other species, which suggests that this cue may be evolutionarily conserved.