Biomimetic oxidation of chromium(III): Does the antidiabetic activity of chromium(III) involve carcinogenic chromium(VI)?

被引：69

作者：

Mulyani, I ^{[1
]}

Levina, A ^{[1
]}

Lay, PA ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期

关键词：

bioinorganic chemistry; biological activity; chromium; enzyme inhibitors; oxidation;

D O I：

10.1002/anie.200460113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The insulin-enhancing activities of some CrIII complexes, such as [Cr3O(OCOEt)6-(OH2)3]+ (1), previously attributed to specific interactions of CrIII ions with cellular insulin receptors, are more likely to be caused by the formation of [CrO4]2- (2). Oxidation of 1 to 2 by biologically relevant oxidants, including enzymes (see scheme), and inhibition of an isolated protein tyrosine phosphatase by a CrVI complex are reported.

引用

页码：4504 / 4507

页数：4

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