Developmental trajectories in early hematopoiesis

被引：18

作者：

Murre, Cornelis ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 20期

关键词：

B-cell development; T-cell development; fate decisions; hematopoiesis; lymphopoiesis; GENE REGULATORY NETWORK; CELL FATE COMMITMENT; B-LYMPHOPOIESIS; T-LYMPHOCYTE; FACTOR EBF; TRANSCRIPTION; E2A; PROTEINS; E47; REARRANGEMENTS;

D O I：

10.1101/gad.1861709

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The paths that hematopoietic stem cells take to develop from multipotent, self-renewing cells into committed lymphocytes has been a topic of debate for some time. During early hematopoiesis, multiple branchpoints have been described in which progeny cells segregate into cell lineages with distinct developmental potentials. In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel.

引用

页码：2366 / 2370

页数：5

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