HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers

被引：64

作者：

Miura, Toshiyuki ^{[1
,2
,3
]}

Brumme, Chanson J. ^{[1
]}

Brockman, Mark A. ^{[1
,2
]}

Brumme, Zabrina L. ^{[1
,2
]}

Pereyra, Florencia ^{[1
,2
]}

Block, Brian L. ^{[2
]}

Trocha, Alicja ^{[1
,3
]}

John, Mina ^{[4
,5
]}

Mallal, Simon ^{[4
,5
]}

Harrigan, P. Richard ^{[6
,7
]}

Walker, Bruce D. ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Ragon Inst, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Div Aids, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[4] Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Perth, WA, Australia

[5] Murdoch Univ, Perth, WA, Australia

[6] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[7] Univ British Columbia, Fac Med, Div Aids, Vancouver, BC, Canada

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 07期

关键词：

CYTOTOXIC T-LYMPHOCYTES; HIV-1; INFECTION; CELL RESPONSES; ESCAPE MUTATIONS; REPLICATION; GAG; VIREMIA; SUPPRESSORS; SELECTION; VARIANTS;

D O I：

10.1128/JVI.02459-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Elite controllers (EC) of human immunodeficiency virus type 1 (HIV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8(+) T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC, compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HIV-1 infection.

引用

页码：3407 / 3412

页数：6

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