Radiotherapy for small-cell lung cancer-Where are we heading?

被引：33

作者：

Bayman, N. A. ^{[1
]}

Sheikh, H. ^{[1
]}

Kularatne, B. ^{[2
]}

Lorigan, P. ^{[2
]}

Blackhall, F. ^{[2
]}

Thatcher, N. ^{[2
]}

Faivre-Finn, C. ^{[1
]}

机构：

[1] Christie Hosp NHS Fdn Trust, Dept Clin Oncol, Manchester M20 4BX, Lancs, England

[2] Christie Hosp NHS Fdn Trust, Dept Med Oncol, Manchester M20 4BX, Lancs, England

来源：

LUNG CANCER | 2009年 / 63卷 / 03期

关键词：

Small-cell lung cancer; Radiotherapy; Thoracic radiotherapy; Fractionation; Prophylactic cranial irradiation; Review; THORACIC RADIATION-THERAPY; COMBINED-MODALITY TREATMENT; PHASE-III TRIAL; PROPHYLACTIC CRANIAL IRRADIATION; LEUKEMIA GROUP-B; LIMITED-STAGE; CONCURRENT CHEMOTHERAPY; CHEST RADIOTHERAPY; RANDOMIZED-TRIAL; PROGNOSTIC-FACTORS;

D O I：

10.1016/j.lungcan.2008.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiotherapy has an established role in the management of limited-disease small-cell lung cancer. However, essential questions related to the optimisation of thoracic radiotherapy remain unanswered including (i) optimal total dose, (ii) fractionation, (iii) timing and sequencing of radiation, (iv) volume of irradiation, and (v) concurrent chemotherapy combinations. The role of thoracic radiotherapy for extensive-disease small-cell lung cancer is more poorly understood but evidence suggests radiotherapy may have an important role in this setting. This review highlights the need for well-designed multi-national trials aimed at the optimisation and standardisation of radiotherapy for SCLC. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：307 / 314

页数：8

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