Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India

被引：104

作者：

Dutta, Deep ^{[1
,2
]}

Mondal, Samim Ali ^{[2
]}

Choudhuri, Subhadip ^{[2
]}

Maisnam, Indira ^{[1
,2
]}

Reza, Abu Hena Hasanoor ^{[2
]}

Bhattacharya, Basudeb ^{[2
]}

Chowdhury, Subhankar ^{[1
,2
]}

Mukhopadhyay, Satinath ^{[1
,2
]}

机构：

[1] IPGMER, Dept Endocrinol & Metab, Kolkata 700020, W Bengal, India

[2] SSKM Hosp, Kolkata 700020, W Bengal, India

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2014年 / 103卷 / 03期

关键词：

Vitamin-D; Prediabetes; Insulin resistance; Systemic inflammation; Diabetes; IMPAIRED GLUCOSE-TOLERANCE; DOUBLE-BLIND; PREVENTION;

D O I：

10.1016/j.diabres.2013.12.044

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p = 0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p = 0.02), associated with decreased insulin resistance and systemic inflammation (TNF alpha and IL6). Baseline vitamin-D and 2 h blood glucose independently predicted progression to diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E18 / E23

页数：6

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