Synovial tissue analysis in rheumatoid arthritis

被引：29

作者：

Bresnihan, B ^{[1
]}

Tak, PP

机构：

[1] St Vincents Univ Hosp, Dept Rheumatol, Dublin 4, Ireland

[2] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Clin Immunol & Rheumatol, NL-1100 DD Amsterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 1999年 / 13卷 / 04期

关键词：

rheumatoid arthritis; synovitis; synovial tissue; inflammation; treatment;

D O I：

10.1053/berh.1999.0051

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

In rheumatoid arthritis, synovial tissue is easily accessible for systematic analysis. Blind needle biopsy is a simple and safe procedure, but is restricted to smaller tissue samples. Arthroscopic biopsy is also safe but is more complicated as it allows access to most sites in the joint and provides adequate tissue for extensive laboratory investigations. Synovial tissue analysis has been successfully applied to studies of disease mechanisms, response to treatment and prognosis. The immuno-histological features in synovial tissue have consistently reflected disease status. Synovial tissue analysis has been particularly informative in the study of novel therapeutic agents.

引用

页码：645 / 659

页数：15

共 82 条

[1]

Arayssi TK, 1998, J RHEUMATOL, V25, P876

[2]

INHIBITION OF THE PRODUCTION AND EFFECTS OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN RHEUMATOID-ARTHRITIS [J].

AREND, WP ;

DAYER, JM .

ARTHRITIS AND RHEUMATISM, 1995, 38 (02) :151-160

[3]

Mechanisms of action of interferon-beta in multiple sclerosis [J].

Arnason, BGW ;

Dayal, A ;

Qu, ZX ;

Jensen, MA ;

Genc, K ;

Reder, AT .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1996, 18 (01) :125-148

[4]

ARNOLD WJ, 1992, B RHEUM DIS, V41, P3

[5]

Bresnihan B, 1998, BRIT J RHEUMATOL, V37, P636

[6]

Bresnihan B, 1998, ARTHRITIS RHEUM, V41, P2196, DOI 10.1002/1529-0131(199812)41:12<2196::AID-ART15>3.3.CO

[7]

2-U

[8]

Interferon-beta(1b) treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis [J].

Brod, SA ;

Marshall, GD ;

Henninger, EM ;

Sriram, S ;

Khan, M ;

Wolinsky, JS .

NEUROLOGY, 1996, 46 (06) :1633-1638

[9]

Microglial production of TNF-alpha is induced by activated T lymphocytes - Involvement of VLA-4 and inhibition by interferon beta-1b [J].

Chabot, S ;

Williams, G ;

Yong, VW .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (03) :604-612

[10]

WHY A RHEUMATOLOGIST SHOULD BE INTERESTED IN ARTHROSCOPY [J].

CHANG, RW ;

SHARMA, L .

ARTHRITIS AND RHEUMATISM, 1994, 37 (11) :1573-1576

← 1 2 3 4 5 6 7 8 9 →