Pharmacodynamics of antimicrobial drugs

被引：208

作者：

Levison, ME

机构：

[1] Drexel Univ, Coll Med, Dept Med, Philadelphia, PA 19129 USA

[2] Drexel Univ, Coll Med, Dept Publ Hlth, Philadelphia, PA 19129 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2004年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.idc.2004.04.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Knowledge of the antimicrobial pharmacodynamic characteristics of a drug (inhibition of growth, rate and extent of bactericidal action, and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval. This article reviews concepts of antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence of resistant bacterial subpopulations, and the development of pharmacodynamic breakpoints for use in the design of trials of these drugs and in treatment of infected patients.

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页码：451 / +

页数：16

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