Genomic structure of murine Rab11 family members

被引：30

作者：

Bhartur, SG

Calhoun, BC

Woodrum, J

Kurkjian, J

Iyer, S

Lai, F

Goldenring, JR

机构：

[1] Med Coll Georgia, Inst Mol Med & Genet, Dept Med, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Surg, Augusta, GA 30912 USA

[3] Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[4] Vet Affairs Med Ctr, Augusta, GA 30912 USA

[5] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 269卷 / 02期

关键词：

D O I：

10.1006/bbrc.2000.2334

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rab11a, Rab11b, and Rab25 in mammals are thought to comprise a subfamily of Rab proteins, although Rab25 has two amino acid differences in its effector domain. We have isolated and characterized the genomic sequences of murine Rab11a and Rab25 and compared them with those of previously characterized mammalian Rab genes. The Rab11a gene spans 29 kb and Rab25 spans 9 kb. The genes have TATA-less promoters, but contain GC-rich areas in their upstream 5' regions. Both genes have 5 exons, with the introns containing characteristic repeats. Rab11a has an unusually long 8.5-kb fourth intron. The Rab11a and Rab25 genes are localized to chromosomes 9C and 3E3/F1, respectively. The overall organization of the Rab11a, Rab11b, and Rab25 genes is similar, with homologous exon-intron boundaries, and differs markedly from those of Rab3A and Rab1A. These results confirm that Rab11A, Rab11b, and Rab25 represent a closely related gene family. (C) 2000 Academic Press.

引用

页码：611 / 617

页数：7

共 27 条

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