共 17 条
The voltage-dependent anion channel as a biological transistor: theoretical considerations
被引:7
作者:
Lemeshko, VV
Lemeshko, SV
机构:
[1] Univ Nacl Colombia, Sch Phys, Dept Sci, Medellin Branch, Medellin, Colombia
[2] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA
来源:
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
|
2004年
/
33卷
/
04期
关键词:
mathematical modeling;
membrane potential;
mitochondrial outer membrane;
Voltage-dependent anion channel;
D O I:
10.1007/s00249-003-0362-3
中图分类号:
Q6 [生物物理学];
学科分类号:
071011 ;
摘要:
The voltage-dependent anion channel (VDAC) is a porin of the mitochondrial outer membrane with a bell-shaped permeability-voltage characteristic. This porin restricts the flow of negatively charged metabolites at certain non-zero voltages, and thus might regulate their flux across the mitochondrial outer membrane. Here, we have developed a mathematical model illustrating the possibility of interaction between two steady-state fluxes of negatively charged metabolites circulating across the VDAC in a membrane. The fluxes interact by contributing to generation of the membrane electrical potential with subsequent closure of the VDAC. The model predicts that the VDAC might function as a single-molecule biological transistor and amplifier, because according to the obtained calculations a small change in the flux of one pair of different negatively charged metabolites causes a significant modulation of a more powerful flux of another pair of negatively charged metabolites circulating across the same membrane with the VDAC. Such transistor-like behavior of the VDAC in the mitochondrial outer membrane might be an important principle of the cell energy metabolism regulation under some physiological conditions.
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页码:352 / 359
页数:8
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