A reevaluation of integrins as regulators of angiogenesis

被引：431

作者：

Hynes, RO ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[2] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm0902-918

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmacological agents directed against the integrins (αvβ3 and αvβ5 have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists.

引用

页码：918 / 921

页数：4

共 58 条

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