Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability

被引：34

作者：

Makioka, Yuko ^{[1
]}

Tsukahara, Takamitsu ^{[2
]}

Ijichi, Tetsuo ^{[1
]}

Inoue, Ryo ^{[3
]}

机构：

[1] Combi Corp, Funct Foods, Saitama, Japan

[2] Kyoto Inst Nutr & Pathol, Kyoto, Japan

[3] Kyoto Prefectural Univ, Lab Anim Sci, Kyoto, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2018年 / 82卷 / 07期

关键词：

Gut microbiota; heat-killed Bifidobacterium; immunostimulation; mouse; HIGH-FAT DIET; PROBIOTICS; CELLS; LIVE;

D O I：

10.1080/09168451.2018.1451738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Effect on cecal microbiota and gene expression of various cytokines in ileal Peyer's patches and cecal tissues were compared between viable and heat-killed Bifidobacterium longum strain BR-108 (BR-108) using a mouse model. Irrespectively of viability, oral supplementation of BR-108 altered the cecal microbiota and stimulated gene expression of cytokines such as IL-6 and IL-10 in ileal Peyer's patches and cecal tissue of mice. In addition, BR-108 supplementation significantly affected the relative abundance of bacterial genera and family, Oscillospira, Bacteroides and S24-7. The abundance of these bacterial genera and family strongly correlated with gene expression induced by BR-108. This study demonstrated that the effect of heat-killed BR-108 on the mouse cecal microbiota is similar to that of viable BR-108, most likely due to stimulation of the gut immune system by both heat-killed and viable BR-108 is also similar.

引用

收藏

页码：1180 / 1187

页数：8

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