The effects of unilateral removal of the cerebellar hemispheres on motor functions and weight gain in rats

被引：33

作者：

Colombel, C ^{[1
]}

Lalonde, R ^{[1
]}

Caston, J ^{[1
]}

机构：

[1] Univ Rouen, Fac Sci, Lab Neurobiol Apprentissage, UPRES PSY CO 1780, F-76821 Mont St Aignan, France

来源：

BRAIN RESEARCH | 2002年 / 950卷 / 1-2期

关键词：

cerebellum; motor skill; motor learning; lateralization;

D O I：

10.1016/S0006-8993(02)03043-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Left or right unilateral removal of a cerebellar hemisphere resulted in a high mortality rate caused by anorexia, not previously seen in cerebellectomized animals. The reduced post-surgical gain in body weight may be explained by oropharyngeal dyspraxia or a loss in appetite. However, the growth rate of the surviving animals was similar to that of controls. After unilateral damage of the cerebellum, deficits were observed in motor coordination tasks, such as the rotorod, the hole-board, and the stationary beam, and the left hemisphere group fell from a suspended wire sooner than controls. The motor deficits were more pronounced after left as opposed to right cerebellar damage on the rotorod, implying a certain degree of functional lateralization for this test. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：231 / 238

页数：8

共 37 条

[1]

REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].