Ropivacaine 0.75% for extradural anaesthesia in elective Caesarean section: An open clinical and pharmacokinetic study in mother and neonate

被引：37

作者：

Morton, CPJ

Bloomfield, S

Magnusson, A

Jozwiak, H

McClure, JH

机构：

[1] ROYAL INFIRM EDINBURGH NHS TRUST,DEPT NEONATAL PAEDIAT,EDINBURGH EH3 9YW,MIDLOTHIAN,SCOTLAND

[2] ASTRA PAIN CONTROL AB,SODERTALJE,SWEDEN

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1997年 / 79卷 / 01期

关键词：

anaesthesia; obstetric; anaesthetic techniques; extradural; anaesthetics local; ropivacaine; pharmacokinetics;

D O I：

10.1093/bja/79.1.3

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In an open study we have investigated the efficacy of 20 ml of 0.75% ropivacaine (7.5 mg ml(-1)) to provide extradural anaesthesia for elective Caesarean section. Plasma concentrations (total and free) were estimated in the mother and neonate. Anaesthesia was effective and safe. Plasma concentrations of ropivacaine in the mother and neonate were within safe limits and consistent with previous studies. Two mothers received accidental i.v. injections of ropivacaine 75 mg and 150 mg, respectively, without serious adverse effects.

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页码：3 / 8

页数：6

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