Mitochondrial iron metabolism in the yeast Saccharomyces cerevisiae

被引：40

作者：

Craig, EA ^{[1
]}

Voisine, C ^{[1
]}

Schilke, B ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA

来源：

BIOLOGICAL CHEMISTRY | 1999年 / 380卷 / 10期

关键词：

Fe-S cluster; frataxin; Hsp70; iron; mitochondria; molecular chaperone;

D O I：

10.1515/BC.1999.148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is fundamental to many biological processes, but is also detrimental as it fosters the synthesis of destructive oxygen radicals. Recent experiments have increased our knowledge of the critical process of regulation of mitochondrial iron metabolism. A number of genes directly involved in iron homeostasis in this organelle have been identified. Intriguingly, a minor Hsp70 molecular chaperone of the mitochondrial matrix has been implicated as a player in this process as well.

引用

页码：1167 / 1173

页数：7

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