Redox regulation of signal transduction in mammalian cells

被引：135

作者：

Herrlich, P

Böhmer, FD

机构：

[1] Forschungszentrum Karlsruhe, Inst Toxicol & Genet, D-76021 Karlsruhe, Germany

[2] Univ Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany

[3] Friedrich Schiller Univ Klinikum, Mol Cell Biol Res Unit, D-07747 Jena, Germany

来源：

BIOCHEMICAL PHARMACOLOGY | 2000年 / 59卷 / 01期

关键词：

receptor tyrosine kinases; protein tyrosine phosphatases; UV response; substrate trapping; platelet-derived growth factor receptor; chemical cross-linking; in-gel phosphatase assay; ligand-independent activation of RTKs; tributyltin; photo-aging;

D O I：

10.1016/S0006-2952(99)00298-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism. BIOCHEM PHARMACOL 59;1:35-41, 2000. (C) 1999 Elsevier Science Inc.

引用

页码：35 / 41

页数：7

共 48 条

[1] Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L [J].