Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

被引：56

作者：

Drexler, Stefan K. ^{[1
]}

Kong, Philip L. ^{[1
]}

Wales, Jeremy ^{[1
]}

Foxwell, Brian M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Rheumatol, Kennedy Inst, London W6 8LH, England

来源：

ARTHRITIS RESEARCH & THERAPY | 2008年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1186/ar2481

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as the adaptive immune systems in the pathology of the disease. The success of anti-tumour necrosis factor-alpha indicates the importance of pro-inflammatory mediators produced by innate immune cells in rheumatoid arthritis progression. Therefore, considerable efforts have been made in elucidating the signalling pathways leading to the expression of those mediators. This review will concentrate on the role of signalling pathways in innate immune cells in the context of rheumatoid arthritis.

引用

页数：12

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