Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients

被引：180

作者：

Ben-Ali, M

Barbouche, MR

Bousnina, S

Chabbou, A

Dellagi, K

机构：

[1] Inst Pasteur, Lab Immunol Vaccinol & Genet Mol, Tunis 1002, Tunisia

[2] CHU Abderrahmen Mami, Serv Pneumo Phtysiol, Ariana, Tunisia

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2004年 / 11卷 / 03期

关键词：

D O I：

10.1128/CDLI.11.3.625-626.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

引用

页码：625 / 626

页数：2

共 13 条

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