Enantioselective nitrone cycloadditions of α,β-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes

被引：135

作者：

Evans, David A. ^{[1
]}

Song, Hyun-Ji ^{[1
]}

Fandrick, Keith R. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 15期

关键词：

1,3-DIPOLAR CYCLOADDITION; ASYMMETRIC CATALYSIS; LANTHANIDE COMPLEXES; ORGANIC-SYNTHESIS; LEWIS-ACID; TRIFLUOROMETHANESULFONATE; ALKYLATIONS; LIGANDS; ALDOL;

D O I：

10.1021/ol061223i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective nitrone cycloadditions with, ss-substituted alpha,ss-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl) pyridine-cerium(IV) triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized, ss'- hydroxy-ss-amino acid derivatives.

引用

页码：3351 / 3354

页数：4

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