Influence of different parameters on reconstitution of lyophilized SLN

被引：102

作者：

Zimmermann, E ^{[1
]}

Müller, RH ^{[1
]}

Mäder, K ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-12169 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 196卷 / 02期

关键词：

solid lipid nanoparticles; lyophilization; colloidal drug carrier;

D O I：

10.1016/S0378-5173(99)00424-X

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Drug-loaded solid lipid nanoparticles (SLN) suitable for parenteral administration were freeze-dried. The lipid matrix Imwitor 900 (concentration, 2.5%) was stabilized with Lipoid E 80 and sodium glycocholate. The influence of different parameters of lyophilization like the protective effect of cryoprotectants, freezing velocity, and thermal treatment was investigated. The results of this study demonstrate that, by optimizing critical process parameters, i.v.-injectable SLN-dispersions can be freeze-dried, preserving their small particle size. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：211 / 213

页数：3

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