Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives

被引：34

作者：

Garbesi, A ^{[1
]}

Bonazzi, S ^{[1
]}

Zanella, S ^{[1
]}

Capobianco, ML ^{[1
]}

Gianni, G ^{[1
]}

Arcamone, F ^{[1
]}

机构：

[1] MENARINI RIC, I-00040 POMEZIA, ROMA, ITALY

来源：

NUCLEIC ACIDS RESEARCH | 1997年 / 25卷 / 11期

关键词：

D O I：

10.1093/nar/25.11.2121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Conjugation of an anthracycline to a tripler-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of the anthraquinone moiety, affords the most stable triple helix, through intercalation of the planar chromophore between DNA bases and binding of both the TFO and the amino sugar to the major and the minor groove respectively.

引用

页码：2121 / 2128

页数：8

共 35 条

[1]

ACTON EM, 1988, ANTHRACYCLINE ANTHRA, P55

[2]

ANIMATI F, 1995, Patent No. 9173

[3]

ANIMATI F, 1995, Patent No. 950406

[4] SOLID-PHASE PREPARATION OF 5', 3'-HETEROBIFUNCTIONAL OLIGODEOXYRIBONUCLEOTIDES USING MODIFIED SOLID SUPPORTS [J].