Role of transforming growth factor-β in the progression of heart failure

被引：144

作者：

Lim, H.

Zhu, Y. Z.

机构：

[1] Natl Univ Singapore, Fac Med, Dept Pharmacol, Singapore 119260, Singapore

[2] Methodist Univ Indonesia, Fac Med, Dept Pharmacol, Medan, Indonesia

[3] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China

[4] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 22期

关键词：

transforming growth factor-beta; signaling pathways; heart tissues; therapeutic options;

D O I：

10.1007/s00018-006-6085-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor (TGF-beta) is a multifunctional peptide growth factor that has an important role in the regulation of cell growth, differentiation, and repair in a variety of tissues. In mammals, the cytokine has three isoforms, TGF-beta 1, TGF-beta 2, and TGF-beta 3. TGF-beta 1 is up-regulated by Ang II and induction of TGF-beta 1 causes cardiac fibrosis. The stimulus that triggers the expression of TGF-beta 1 may be repeated causing continual injury, which is associated with an increase in the activity of Ang II in heart tissue. The interplay between Ang II and TGF-beta 1 causes continued activation that may result in chronic hypertension and progressive myocardial fibrosis, leading to heart failure. The regulation of TGF-beta 1 secretion and action involves complex transcriptional events. Overproduction of TGF-beta 1 underlies tissue fibrosis. Understanding the actions and signaling transduction of TGF-beta could lead to the development of therapeutic options that may be effective in inhibiting myocardial fibrosis triggered by TGF-beta 1 in heart failure.

引用

页码：2584 / 2596

页数：13

共 147 条

[1] Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts [J].