Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation

被引：719

作者：

Bertet, C ^{[1
]}

Sulak, L ^{[1
]}

Lecuit, T ^{[1
]}

机构：

[1] Univ Mediterranee, Lab Genet & Physiol Dev, Inst Biol Dev Marseille, CNRS,INSERM, F-13288 Marseille 9, France

来源：

NATURE | 2004年 / 429卷 / 6992期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nature02590

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Shaping a developing organ or embryo relies on the spatial regulation of cell division and shape. However, morphogenesis also occurs through changes in cell-neighbourhood relationships produced by intercalation(1,2). Intercalation poses a special problem in epithelia because of the adherens junctions, which maintain the integrity of the tissue. Here we address the mechanism by which an ordered process of cell intercalation directs polarized epithelial morphogenesis during germ-band elongation, the developmental elongation of the Drosophila embryo. Intercalation progresses because junctions are spatially reorganized in the plane of the epithelium following an ordered pattern of disassembly and reassembly. The planar remodelling of junctions is not driven by external forces at the tissue boundaries but depends on local forces at cell boundaries. Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are required for planar junction remodelling and cell intercalation. This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs.

引用

页码：667 / 671

页数：5

共 29 条

[1] Cytomechanics of cadherin-mediated cell-cell adhesion [J].