Anti-HMGCR Autoantibodies in European Patients With Autoimmune Necrotizing Myopathies Inconstant Exposure to Statin

被引：232

作者：

Allenbach, Yves ^{[1
,2
]}

Drouot, Laurent ^{[3
,4
]}

Rigolet, Aude ^{[1
,2
]}

Charuel, Jean Luc ^{[5
]}

Jouen, Fabienne ^{[3
,4
]}

Romero, Norma B. ^{[6
]}

Maisonobe, Thierry ^{[7
]}

Dubourg, Odile ^{[7
]}

Behin, Anthony ^{[8
]}

Laforet, Pascal ^{[8
]}

Stojkovic, Tania ^{[8
]}

Eymard, Bruno ^{[8
]}

Costedoat-Chalumeau, Nathalie ^{[9
]}

Campana-Salort, Emmanuelle ^{[10
]}

Tournadre, Anne ^{[11
]}

Musset, Lucile ^{[5
]}

Bader-Meunier, Brigitte ^{[12
]}

Kone-Paut, Isabelle ^{[13
]}

Sibilia, Jean ^{[14
]}

Servais, Laurent ^{[15
]}

Fain, Olivier ^{[16
]}

Larroche, Claire ^{[17
]}

Diot, Elisabeth ^{[18
]}

Terrier, Benjamin ^{[9
]}

De Paz, Raphael ^{[19
]}

Dossier, Antoine ^{[20
]}

Menard, Dominique ^{[21
]}

Morati, Chafika ^{[22
]}

Roux, Marielle ^{[23
]}

Ferrer, Xavier ^{[24
]}

Martinet, Jeremie ^{[3
,4
]}

Besnard, Sophie ^{[25
]}

Bellance, Remi

Cacoub, Patrice ^{[26
]}

Arnaud, Laurent ^{[26
]}

Grosbois, Bernard ^{[25
]}

Herson, Serge ^{[1
,2
]}

Boyer, Olivier ^{[3
,4
]}

Benveniste, Olivier ^{[1
,2
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Dept Internal Med 1, F-75013 Paris, France

[2] Univ Paris 06, INSERM, Inflammat Immunopathol Biotherapy Dept I2B, East Paris Neuromuscular Dis Reference Ctr,U974, F-75013 Paris, France

[3] Normandie Univ, IRIB, INSERM, U905,Immunol Dept, Caen, France

[4] Rouen Univ Hosp, Rouen, France

[5] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Immunochem, F-75013 Paris, France

[6] Hop La Pitie Salpetriere, AP HP, Inst Myol, Unite Morphol Musculaire,CNRS,UMR7215, F-75013 Paris, France

[7] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Neuropathol, F-75013 Paris, France

[8] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Neurol,East Paris Neuromuscular Dis Referenc, F-75013 Paris, France

[9] Univ Paris 05, Hop Cochin, AP HP, Serv Med Interne Pole Med,Ctr Reference Malad Aut, Paris, France

[10] Hop Enfants La Timone, APHM, Ctr Reference Malad Neuromusculaires, Marseille, France

[11] Clermont Ferrand Univ Hosp, Dept Rheumatol, Clermont Ferrand, France

[12] Hop Necker Enfants Malad, AP HP, Dept Paediat Rheumatol, Paris, France

[13] Hop Bicetre, AP HP, Dept Paediat Rheumatol, Paris, France

[14] CHU Strasbourg, Dept Rheumatol, F-67000 Strasbourg, France

[15] Hop La Pitie Salpetriere, Inst Myol, F-75013 Paris, France

[16] Hop Jean Verdier, AP HP, Dept Internal Med, La Seine St Denis, France

[17] Hop Avicenne, AP HP, Dept Internal Med, F-93009 Bobigny, France

[18] CHRU Tours, Dept Internal Med, Tours, France

[19] Fondat A Rothschild, Dept Neurol, Paris, France

[20] Hop Bichat Claude Bernard, AP HP, Dept Internal Med, F-75877 Paris, France

[21] CHU Rennes, Dept Neurol, Rennes, France

[22] Ctr Hosp Reg Annecy, Dept Internal Med, Annecy, France

[23] Hop Pierre Oudot, Dept Internal Med, Bourgouin, France

[24] Hop Haut Leveque, Dept Neurol, Bordeaux, France

[25] CHU Rennes, Dept Internal Med, Rennes, France

[26] Univ Paris 06, Hop La Pitie Salpetriere, AP HP,Dept Internal Med 2, Dept Hosp Univ I2B,UMR 7211,INSERM,UMRS 959, F-75013 Paris, France

来源：

MEDICINE | 2014年 / 93卷 / 03期

关键词：

SIGNAL RECOGNITION PARTICLE; IDIOPATHIC INFLAMMATORY MYOPATHY; REVISED CRITERIA; CLASSIFICATION; ANTI-3-HYDROXY-3-METHYLGLUTARYL-COENZYME; POLYMYOSITIS;

D O I：

10.1097/MD.0000000000000028

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-exposed patients. Here we report what is to our knowledge the first European cohort of patients with NAM. The serum of 206 patients with suspicion of NAM was tested for detection of anti-HMGCR aAb using an addressable laser bead immunoassay. Forty-five patients were found to be anti-HMGCR positive. Their mean age was 48.9 +/- 21.9 years and the group was predominantly female (73.3%). Statin exposure was recorded in 44.4% of patients. Almost all patients had a muscular deficit (97.7%), frequently severe (Medical Research Council [MRC] 5 <= 3 in 75.5%). Subacute onset (< 6 mo) was noted for most of them (64.4%). Nevertheless, 3 patients (6.6%) had a slowly progressive course over more than 10 years. Except for weight loss (20%), no extramuscular sign was observed. The mean CK level was high (6941 +/- 8802 IU/L) and correlated with muscle strength evaluated by manual muscle testing (r = -0.37, p = 0.03). Similarly, anti-HMGCR aAb titers were correlated with muscular strength (r = -0.31; p = 0.03) and CK level (r = 0.45; p = 0.01). Mean duration of treatment was 34.1 +/- 40.8 months, and by the end of the study no patient had been able to stop treatment. This study confirms the observation and description of anti-HMGCR aAb associated with NAM. The majority of patients were statin naive and needed prolonged treatments. Some patients had a dystrophic-like presentation. Anti-HMGR aAb titers correlated with CK levels and muscle strength, suggesting their pathogenic role.

引用

页码：150 / 157

页数：8

共 18 条

[1]

THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[2]

Correlation of Anti-Signal Recognition Particle Autoantibody Levels With Creatine Kinase Activity in Patients With Necrotizing Myopathy [J].

Benveniste, Olivier ;

Drouot, Laurent ;

Jouen, Fabienne ;

Charuel, Jean-Luc ;

Bloch-Queyrat, Coralie ;

Behin, Anthony ;

Amoura, Zahir ;

Marie, Isabelle ;

Guiguet, Marguerite ;

Eymard, Bruno ;

Gilbert, Daniele ;

Tron, Francois ;

Herson, Serge ;

Musset, Lucile ;

Boyer, Olivier .

ARTHRITIS AND RHEUMATISM, 2011, 63 (07) :1961-1971

[3]

POLYMYOSITIS AND DERMATOMYOSITIS .1. [J].

BOHAN, A ;

PETER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (07) :344-347

[4]

Necrotising myopathy, an unusual presentation of a steroid-responsive myopathy [J].

Bronner, IM ;

Hoogendijk, JE ;

Wintzen, AR ;

van der Meulen, MFG ;

Linssen, WHJP ;

Wokke, JHJ ;

de Visser, M .

JOURNAL OF NEUROLOGY, 2003, 250 (04) :480-485

[5]

A Novel Autoantibody Recognizing 200-kd and 100-kd Proteins Is Associated With an Immune-Mediated Necrotizing Myopathy [J].

Christopher-Stine, Lisa ;

Casciola-Rosen, Livia A. ;

Hong, Grace ;

Chung, Tae ;

Corse, Andrea M. ;

Mammen, Andrew L. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2757-2766

[6]

Exploring necrotizing autoimmune myopathies with a novel immunoassay for anti-3-hydroxy-3-methyl-glutaryl-CoA reductase autoantibodies [J].

Drouot, Laurent ;

Allenbach, Yves ;

Jouen, Fabienne ;

Charuel, Jean-Luc ;

Martinet, Jeremie ;

Meyer, Alain ;

Hinschberger, Olivier ;

Bader-Meunier, Brigitte ;

Kone-Paut, Isabelle ;

Campana-Salort, Emmanuelle ;

Eymard, Bruno ;

Tournadre, Anne ;

Musset, Lucile ;

Sibilia, Jean ;

Marie, Isabelle ;

Benveniste, Olivier ;

Boyer, Olivier .

ARTHRITIS RESEARCH & THERAPY, 2014, 16 (01)

[7]

INCLUSION-BODY MYOSITIS AND MYOPATHIES [J].

GRIGGS, RC ;

ASKANAS, V ;

DIMAURO, S ;

ENGEL, A ;

KARPATI, G ;

MENDELL, JR ;

ROWLAND, LP .

ANNALS OF NEUROLOGY, 1995, 38 (05) :705-713

[8]

Hoogendijk JE, 2003, NEUROMUSCUL DISORD

[9]

Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy [J].

Kao, AH ;

Lacomis, D ;

Lucas, M ;

Fertig, N ;

Oddis, CV .

ARTHRITIS AND RHEUMATISM, 2004, 50 (01) :209-215

[10]

Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effects [J].

Mammen, Andrew L. ;

Pak, Katherine ;

Williams, Emma K. ;

Brisson, Diane ;

Coresh, Joe ;

Selvin, Elizabeth ;

Gaudet, Daniel .

ARTHRITIS CARE & RESEARCH, 2012, 64 (02) :269-272

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