Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

被引：195

作者：

Carriere, Catherine ^{[1
,2
,3
,4
]}

Young, Alison L. ^{[1
,2
,3
,4
]}

Gunn, Jason R. ^{[1
,2
,3
,4
]}

Longnecker, Daniel S. ^{[5
]}

Korc, Murray ^{[1
,2
,3
,4
]}

机构：

[1] Dartmouth Med Sch, Dept Med, Hanover, NH 03755 USA

[2] Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03755 USA

[3] Dartmouth Med Sch, Dept Toxicol, Hanover, NH 03755 USA

[4] Dartmouth Hitchcock Med Ctr, Norris Cotton Comprehens Canc Ctr, Lebanon, NH 03756 USA

[5] Dartmouth Med Sch, Dept Pathol, Hanover, NH 03755 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 382卷 / 03期

关键词：

Kras(G12D); PDAC; Acute pancreatitis; ACINAR-CELL; REGENERATION; INDUCTION; LINEAGE;

D O I：

10.1016/j.bbrc.2009.03.068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Chronic pancreatitis increases by 16-fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. It also appears to accelerate cancer progression in genetically engineered mouse models. We now report that in a mouse model where oncogenic Kras is activated in all pancreatic cell types, two brief episodes of acute pancreatitis caused rapid PanIN progression and accelerated pancreatic cancer development. Thus, a brief inflammatory insult to the pancreas, when occurring in the context of oncogenic Kras(G12D), can initiate a cascade of events that dramatically enhances the risk for pancreatic malignant transformation. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：561 / 565

页数：5

共 26 条

[1]

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma [J].

Aguirre, AJ ;

Bardeesy, N ;

Sinha, M ;

Lopez, L ;

Tuveson, DA ;

Horner, J ;

Redston, MS ;

DePinho, RA .

GENES & DEVELOPMENT, 2003, 17 (24) :3112-3126

[2]

The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia [J].

Carriere, Catherine ;

Seeley, Elliott S. ;

Goetze, Tobias ;

Longnecker, Daniel S. ;

Korc, Murray .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (11) :4437-4442

[3]

Preexisting pancreatic to acinar cell, but not islet β cell, regeneration [J].

Desai, Biva M. ;

Oliver-Krasinski, Jennifer ;

De Leon, Diva D. ;

Farzad, Cyrus ;

Hong, Nankang ;

Leach, Steven D. ;

Stoffers, Doris A. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (04) :971-977

[4]

Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans [J].

Ebert, M ;

Yokoyama, M ;

Ishiwata, T ;

Friess, H ;

Büchler, MW ;

Malfertheiner, P ;

Korc, M .

PANCREAS, 1999, 18 (03) :240-246

[5]

Hedgehog signaling is required for effective regeneration of exocrine pancreas [J].

Fendrich, Volker ;

Esni, Farzad ;

Garay, Maria Veronica R. ;

Feldmann, Georg ;

Habbe, Nils ;

Jensen, Jan Nygaard ;

Dor, Yuval ;

Stoffers, Doris ;

Jensen, Jan ;

Leach, Steven D. ;

Maitra, Anirban .

GASTROENTEROLOGY, 2008, 135 (02) :621-631

[6]

Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury [J].

Grady, T ;

MaH'Moud, M ;

Otani, T ;

Rhee, S ;

Lerch, MM ;

Gorelick, FS .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 275 (05) :G1010-G1017

[7]

Gu GQ, 2002, DEVELOPMENT, V129, P2447

[8]

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice [J].

Guerra, Carmen ;

Schuhmacher, Alberto J. ;

Canamero, Marta ;

Grippo, Paul J. ;

Verdaguer, Lena ;

Perez-Gallego, Lucia ;

Dubus, Pierre ;

Sandgren, Eric P. ;

Barbacid, Mariano .

CANCER CELL, 2007, 11 (03) :291-302

[9]

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice [J].

Habbe, Nils ;

Shi, Guanglu ;

Meguid, Robert A. ;

Fendrich, Volker ;

Esni, Farzad ;

Chen, Huiping ;

Feldmann, Georg ;

Stoffers, Doris A. ;

Konieczny, Stephen F. ;

Leach, Steven D. ;

Maitra, Anirban .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (48) :18913-18918

[10]

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse [J].

Hingorani, SR ;

Petricoin, EF ;

Maitra, A ;

Rajapakse, V ;

King, C ;

Jacobetz, MA ;

Ross, S ;

Conrads, TP ;

Veenstra, TD ;

Hitt, BA ;

Kawaguchi, Y ;

Johann, D ;

Liotta, LA ;

Crawford, HC ;

Putt, ME ;

Jacks, T ;

Wright, CVE ;

Hruban, RH ;

Lowy, AM ;

Tuveson, DA .

CANCER CELL, 2003, 4 (06) :437-450

← 1 2 3 →