Rolling in the clover: Trefoil factor family (TFF)-domain peptides, cell migration and cancer

被引：150

作者：

Wright, NA

Hoffmann, W

Otto, WR

Rio, MC

Thim, L

机构：

[1] UNIV MAGDEBURG,INST MOL BIOL & MED CHEM,D-39120 MAGDEBURG,GERMANY

[2] UNIV STRASBOURG 1,INST GENET BIOL MOL & CELLULAIRE,INSERM,U184,STRASBOURG,FRANCE

[3] NOVO NORDISK AS,DEPT PROT CHEM,DK-2880 BAGSVAERD,DENMARK

来源：

FEBS LETTERS | 1997年 / 408卷 / 02期

关键词：

trefoil factor family; TFF-domain peptide; cancer; cell migration; ulcer; invasion;

D O I：

10.1016/S0014-5793(97)00424-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues, Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours, A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides. (C) 1997 Federation of European Biochemical Societies.

引用

页码：121 / 123

页数：3

共 20 条

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