Control of Mycobacterium tuberculosis through mammalian Toll-like receptors

被引：110

作者：

Stenger, S

Modlin, RL

机构：

[1] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(02)00355-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An efficient immune response against the intracellular pathogen Mycobacterium tuberculosis is critically dependent on rapid detection of the invader by the innate immune response and the activation of the adaptive immune response. Toll-like receptors (TLRs) contribute to innate immunity by the detection of Mycobacteria-associated molecular patterns and mediating the secretion of antibacterial effector molecules. TLRs influence the adaptive immune response by upregulation of immunomodulatory molecules supporting the development of a Th1-biased T cell response. In this manner, activation of TLRs contributes to defense against microbial infection.

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页码：452 / 457

页数：6

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