Cerebral cystine uptake: a tale of two transporters

被引：132

作者：

McBean, GJ ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Dept Biochem, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 07期

关键词：

D O I：

10.1016/S0165-6147(02)02060-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transport of cystine across the cell membrane is essential for synthesis of the major cellular aintioxidant glutathione. Cystine uptake in the brain occurs by both the Na+-independent x(c)(-) cystine-glutamate exchanger and the X-AG(-) family of high-affinity, Na+-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described.

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页码：299 / 302

页数：4

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