Chitosan-based systems for the delivery of vaccine antigens

被引：49

作者：

Arca, H. Cigdem ^{[1
]}

Guenbeyaz, Merve ^{[1
]}

Senel, Sevda ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey

来源：

EXPERT REVIEW OF VACCINES | 2009年 / 8卷 / 07期

关键词：

chitosan; chitosan derivative; mucosal vaccination; nasal; vaccine delivery; veterinary; MUCOSAL IMMUNE-RESPONSES; BORDETELLA-BRONCHISEPTICA ANTIGENS; NASAL DELIVERY; INTRANASAL IMMUNIZATION; CONJUGATE VACCINE; IN-VITRO; NEUTRALIZING ANTIBODIES; TMC NANOPARTICLES; DRUG-DELIVERY; CPG ODN;

D O I：

10.1586/ERV.09.47

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

This review discusses the current status of chitosan and its derivatives as adjuvants and delivery systems in vaccine delivery, and their future possibilities and challenges. After a brief introduction to adjuvants and delivery systems, chitosan will be described in detail in regard to vaccine formulation. Applications of chitosan and its derivatives will be reviewed and their proposed mechanisms in the enhancement of immune responses will be discussed.

引用

页码：937 / 953

页数：17

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