Using Allele Sharing Distance for Detecting Human Population Stratification

被引：34

作者：

Gao, Xiaoyi ^{[1
]}

Martin, Eden R. ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Div Stat Genom, St Louis, MO 63108 USA

[2] Univ Miami, Miller Sch Med, Miami Inst Human Genom, Ctr Genet Epidemiol & Stat Genet, Miami, FL 33136 USA

来源：

HUMAN HEREDITY | 2009年 / 68卷 / 03期

关键词：

Population stratification; Coancestry coefficient; Single nucleotide polymorphism; Allele sharing distance; RELATEDNESS; ASSOCIATION;

D O I：

10.1159/000224638

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is a long history of using allele sharing distance (ASD) and closely related metrics for population stratification analysis. However, the theory for this practical usage has not been reported. In this paper, we describe the theoretical background for using ASD on single nucleotide polymorphism ( SNP) genetic data for human population stratification analysis. In showing the proof, we lay the ground work for a general distance-based method for classifying subpopulations using SNPs and ASD. We also show its relation to other closely related distance metrics using HapMap Phase I SNP data. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：182 / 191

页数：10

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