Gastrula organiser and embryonic patterning in the mouse

被引：99

作者：

Robb, L

Tam, PPL

机构：

[1] Childrens Med Res Inst, Embryol Unit, Wentworthville, NSW 2145, Australia

[2] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 05期

基金：

英国医学研究理事会;

关键词：

organiser; axial mesoderm; embryonic patterning; signalling activity; mouse embryo;

D O I：

10.1016/j.semcdb.2004.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic patterning of the mouse during gastrulation and early organogenesis engenders the specification of anterior versus posterior structures and body laterality by the interaction of signalling and modulating activities. A group of cells in the mouse gastrula, characterised by the expression of a repertoire of "organiser" genes, acts as a source and the conduit for allocation of the axial mesoderm, floor plate and definitive endoderm. The organiser and its derivatives provide the antagonistic activity that modulates WNT and TGFbeta signalling. Recent findings show that the organiser activity is augmented by morphogenetic activity of the extraembryonic and embryonic endoderm, suggesting embryonic patterning is not solely the function of the organiser. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：543 / 554

页数：12

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